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Dementia01:30

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Related Experiment Video

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Using Retinal Imaging to Study Dementia
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Precision Medicine for Frontotemporal Dementia.

Mu-N Liu1,2,3, Chi-Ieong Lau4,5,6, Ching-Po Lin1,7,8

  • 1Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.

Frontiers in Psychiatry
|March 9, 2019
PubMed
Summary

Frontotemporal dementia (FTD) is a young-onset dementia with varied symptoms. Precision medicine offers personalized treatments by considering individual neuroimaging, neuropathology, and genetics for FTD management.

Keywords:
frontotemporal dementiafrontotemporal lobar degenerationgeneticsneuroimagingprecision medicineprimary progressive aphasia

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Area of Science:

  • Neurology
  • Neuroscience
  • Precision Medicine

Background:

  • Frontotemporal dementia (FTD) is a prevalent cause of young-onset dementia.
  • FTD presents with diverse syndromes affecting behavior, language, and executive functions.
  • FTD's behavioral symptoms can mimic psychiatric disorders.

Purpose of the Study:

  • To review the pathophysiology of FTD, focusing on frontal and temporal cortex degeneration.
  • To discuss recent advancements in FTD research across clinical, imaging, and molecular aspects.
  • To highlight the application of precision medicine in managing FTD's complexities.

Main Methods:

  • Review of current literature on FTD pathophysiology.
  • Analysis of recent research in clinical, imaging, and molecular FTD characterizations.
  • Exploration of precision medicine strategies for FTD.

Main Results:

  • FTD involves selective degeneration of frontal and temporal cortices.
  • Advancements include improved clinical diagnosis, novel imaging techniques, and molecular insights.
  • Precision medicine enables personalized treatment strategies based on individual patient profiles.

Conclusions:

  • FTD pathophysiology involves specific cortical degeneration.
  • Integrated research approaches are advancing FTD understanding and treatment.
  • Precision medicine is a promising framework for personalized FTD management.