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Published on: October 17, 2018
Zika Virus Infection, Basic and Clinical Aspects: A Review Article
Farshid Noorbakhsh1, Kamal Abdolmohammadi1,2,3, Yousef Fatahi4,5
1Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Background:
Zika virus infection has recently attracted the attention of medical community. While clinical manifestations of the infection in adult cases are not severe and disease is not associated with high mortality rates, Zika virus infection can have an impact on fetal development and lead to severe neurodevelopmental abnormalities.
Methods:
To gain insight into different aspects of Zika virus infection, a comprehensive literature review was performed. With regard to epidemiology and geographical distribution of Zika virus infection, relevant information was extracted from CDC and WHO websites.
Results:
In this review, we discuss different basic and clinical aspects of Zika virus infection including virology, epidemiology and pathogenesis of disease. Laboratory methods required for the diagnosis of disease together with ethical issues associated with Zika virus infection will also be discussed in detail.
Conclusion:
Herein, we have tried to provide a multi-faceted view of Zika virus infection, with greater emphasis on disease status in Eastern Mediterranean Region.
Insights
Zika virus infection poses minimal risk to adults but severe risks to fetal development, causing neurodevelopmental abnormalities. This review details Zika virus, its epidemiology, and diagnostic methods.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Zika virus infection, while generally mild in adults, poses significant risks to fetal development, leading to severe neurodevelopmental abnormalities.
- The medical community has recently focused on Zika virus due to its potential teratogenic effects.
Purpose of the Study:
- To provide a comprehensive review of Zika virus infection, covering its basic and clinical aspects.
- To detail the epidemiology, geographical distribution, virology, and pathogenesis of Zika virus disease.
- To discuss diagnostic laboratory methods and ethical considerations related to Zika virus infection.
Main Methods:
- A comprehensive literature review was conducted to gather information on Zika virus.
- Data on epidemiology and geographical distribution were extracted from CDC and WHO websites.
Main Results:
- The review covers various aspects of Zika virus infection, including its virology, epidemiology, and pathogenesis.
- Diagnostic laboratory methods and ethical concerns are discussed in detail.
Conclusions:
- This review offers a multi-faceted perspective on Zika virus infection.
- Emphasis is placed on the disease's status within the Eastern Mediterranean Region.
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