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Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Yaqing Shu1, Youming Long2, Shisi Wang1

  • 1Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou 510630 China.

Annals of Clinical and Translational Neurology
|March 9, 2019
PubMed

Insights

Myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor, a rare condition, shows MS-like pathology. Immunotherapy with steroids and rituximab led to favorable outcomes in two patients.

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Investigating myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor (MOGAD pseudotumor).
  • Understanding the histopathology and prognosis of this rare demyelinating condition.

Observation:

  • Reviewed clinical, MRI, and histological features of two MOGAD pseudotumor patients.
  • Brain biopsies revealed T cells, macrophages, and complement-mediated demyelination.
  • Pathology findings were consistent with multiple sclerosis-like lesions.

Findings:

  • Both patients received steroid plus rituximab therapy.
  • Both cases demonstrated a favorable response to the immunotherapy regimen.
  • Histopathology confirmed demyelination and inflammatory infiltrates.

Implications:

  • MOGAD pseudotumor represents a distinct variant within the MOGAD spectrum.
  • The condition shows a positive response to immunotherapy, including steroids and rituximab.
  • These findings expand understanding of MOGAD variants and treatment strategies.

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