Related Experiment Video
Updated: Jan 28, 2026
05:51
Coculture Analysis of Extracellular Protein Interactions Affecting Insulin Secretion by Pancreatic Beta Cells
Published on: June 15, 2013
13.4K
Nanomedical Relevance of the Intermolecular Interaction Dynamics-Examples from Lysozymes and Insulins
Ruiyan Zhang1,2,3, Ning Zhang1, Marzieh Mohri2
1Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.
ACS Omega
|March 9, 2019
Summary
This study reveals atomistic details of insulin and lysozyme homo-oligomerization, crucial for designing protein-loaded nanoparticles for oral drug delivery.
Area of Science:
- Biophysics
- Nanotechnology
- Protein Chemistry
Background:
- Insulin and lysozyme are biomedically important proteins prone to aggregation.
- Understanding their oligomerization is key for developing nanoparticle-based drug delivery systems.
Purpose of the Study:
- To elucidate the atomistic interaction dynamics during insulin and lysozyme homo-oligomerization.
- To provide insights for designing effective encapsulation protocols in micellar nanoparticles.
Main Methods:
- Nuclear Magnetic Resonance (NMR) spectroscopy
- X-ray crystallography
- Thioflavin T fluorescence
- Atomic Force Microscopy (AFM)
- Molecular modeling
Main Results:
- Detailed atomistic intra- and intermolecular interaction profiles of insulin and lysozyme homo-oligomers were elucidated.
- The propensity of these proteins to form fibrils was confirmed.
- Environmental factors influencing oligomerization dynamics were investigated.
Conclusions:
- The gained knowledge facilitates the design and production of insulin and lysozyme-loaded nanoparticles.
- This research supports advancements in oral protein drug delivery systems.
Related Concept Videos
02:28Intermolecular Forces in Solutions
39.3K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
39.3K
03:13Intermolecular Forces
70.7K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
70.7K
03:00Intermolecular vs Intramolecular Forces
96.6K
Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular force is influenced by the distance of separation between molecules. The forces significantly affect the interactions in solids and liquids, where the molecules are close together. In gases, IMFs become important only under high-pressure conditions (due to the proximity of gas molecules). Intermolecular forces dictate the physical properties of...
96.6K
02:34Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility
51.3K
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
51.3K
01:08Newton's Third Law: Examples
27.0K
Newton's third law states that every action has an equal and opposite reaction. Consider a swimmer pushing off the side of a pool. They push against the wall of the pool with their feet and accelerate in the direction opposite to that of their push. This occurs because the wall exerts an equal and opposite force on the swimmer. Here, the forces do not cancel out each other as they are acting on different systems. In this case, there are two systems: the swimmer and the wall. If we select...
27.0K
01:07Free Body Diagrams: Examples
14.7K
Solving problems that involve forces is easy using free-body diagrams. A free-body diagram is a sketch showing all the external forces that are acting on an object or system. The object or system is represented by a single isolated point (or free body). Only those forces acting on it that originate outside of the object or system—the external forces—are shown. The forces are represented by vectors extending outward from the free body. Imagine a person sitting on a chair. Here, the...
14.7K