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New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata
Yusuke Hirasawa1, Xin Dai1, Jun Deguchi1
1Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
Journal of Natural Medicines
|March 9, 2019
Abstract:
Taberniacins A (1) and B (2), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

