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Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging.

Peter J Niedbalski1, Matthew M Willmering1, Scott H Robertson2

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Quantifying hyperpolarized (HP) MRI is challenging due to signal decay. This study introduces a method combining center-out sampling and keyhole reconstruction to map regional HP magnetization decay, improving image accuracy.

Keywords:
129XeUTEhyperpolarizationkeyholepulmonaryradialventilation

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Area of Science:

  • Biomedical Imaging
  • Magnetic Resonance Imaging (MRI)

Background:

  • Hyperpolarized (HP) media offer advanced biomedical imaging capabilities beyond conventional MRI contrast agents.
  • Quantifying HP images is difficult due to spatially varying signal decay caused by relaxation and radio-frequency pulsing during acquisition.

Purpose of the Study:

  • To develop a method for generating voxel-by-voxel maps of regional HP magnetization decay.
  • To address the challenge of quantifying HP images by correcting for signal decay.

Main Methods:

  • Utilized center-out k-space sampling combined with postacquisition keyhole reconstruction.
  • Reconstructed datasets from digital phantoms, HP 129 Xe phantoms, and in vivo human HP 129 Xe imaging (N=6).
  • Generated temporally resolved images to create regional magnetization decay maps using an analytical model.

Main Results:

  • Keyhole-derived decay terms strongly agreed with simulated and phantom imaging decay values (R2 > 0.97).
  • In vivo regional decay maps showed spatial heterogeneity consistent with physiological variations and agreed with global decay.
  • Demonstrated the ability of these maps to correct for variable signal decay across image volumes.

Conclusions:

  • Center-out trajectories and keyhole reconstruction effectively map regional HP signal decay.
  • This technique enables quantitative correction of HP images, enhancing accuracy.
  • The method is generalizable to various hyperpolarized agents beyond the demonstrated HP 129 Xe.