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Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

Erik A H Loeffen1, Leontien C M Kremer2,3, Marianne D van de Wetering2

  • 1University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Oncology/Hematology, Groningen, the Netherlands.

Pediatric Blood & Cancer
|March 9, 2019
PubMed

Insights

Developing evidence-based guidelines for pediatric cancer pain management is crucial due to its prevalence. This study outlines the methodology for creating a clinical practice guideline for assessing and managing pain in children with cancer.

Area of Science:

  • Pediatric Oncology
  • Pain Management
  • Clinical Practice Guidelines

Background:

  • Pain is a common and distressing symptom for children with cancer.
  • There is a lack of evidence-based guidance for assessing and managing pediatric cancer pain.
  • Multidisciplinary input is essential for comprehensive pain management strategies.

Purpose of the Study:

  • To develop a clinical practice guideline for the assessment and management of tumor-, treatment-, and procedure-related pain in children with cancer.
  • To address pharmacological, psychological, and physical pain management modalities.
  • To provide evidence-based recommendations for healthcare professionals.

Main Methods:

  • The guideline development followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.
  • Involved 44 international, multidisciplinary healthcare professionals and nine patient representatives.
  • Detailed methodology, including challenges and approaches, is presented.

Main Results:

  • The methodology for guideline development was rigorously established.
  • Challenges encountered during the development process were identified and addressed.
  • The foundation for a high-demand clinical practice guideline was laid.

Conclusions:

  • A comprehensive methodology was employed to develop a clinical practice guideline for pediatric cancer pain.
  • The guideline addresses various aspects of pain assessment and management.
  • This work provides a framework for improving pain care in children with cancer.

Keywords:
clinical practice guidelineevidence-based medicinepainpediatric oncologysupportive care

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