Related Experiment Video
Updated: Jan 28, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
LINC00473 mediates cyclin D1 expression through a balance between activation and repression signals in breast cancer
Xiangmin Shi1,2, Xiangting Wang1,2
1Hefei National Laboratory for Physical Sciences at the Microscale, Hefei, Anhui, China.
Abstract:
Long noncoding RNAs (lncRNAs) are critical regulators in tumorigenesis. However, their roles in breast cancer remain unclear. Here, we found that lncRNA LINC00473 is significantly upregulated in breast cancer cells. Loss- or gain-of-function experiments show that LINC00473 promotes cell proliferation. Mechanistically, LINC00473 is required for the activation of cyclin D1 (CCND1) expression through recruitment of phosphorylated CREB and histone acetylation to the CCND1 promoter. Interestingly, we found that LINC00473 is also required for maintaining the expression levels of the noncoding RNACCND1 s and recruiting corepressor FUS to the CCND1 promoter. Altogether, the activation effect of LINC00473 on CCND1 is a net effect of two antagonistic regulatory pathways. Our finding provides a novel lncRNA-mediated precise transcriptional control of CCND1.
Related Concept Videos
What is Cell Signaling?
Repressed Memory
Cell-surface Signaling
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Balancing Redox Equations

