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This study introduces a simple, paper-based viscometer for measuring blood plasma viscosity, offering a convenient and accurate method for clinical diagnosis. The device uses colorimetric analysis and a smartphone app for easy data interpretation.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Clinical Diagnostics

Background:

  • Biofluid viscosity offers valuable patient health insights but is underutilized clinically due to complex methods and large sample requirements.
  • Current viscosity measurement techniques are often cumbersome, hindering widespread clinical adoption.

Purpose of the Study:

  • To develop a novel, paper-based viscometer for accurate and convenient measurement of blood plasma viscosity.
  • To enable clinical diagnosis by simplifying viscosity measurements using colorimetric analysis.

Main Methods:

  • Fabrication of a multilayered paper device with distinct fluid handling regions.
  • Utilization of colorimetric analysis on a single optical image for viscosity estimation.
  • Development of a smartphone application to enhance user convenience and data analysis.

Main Results:

  • The paper-based viscometer demonstrated accurate viscosity measurements for various fluids, including blood plasma, showing good agreement with reference values.
  • The device's performance was validated using glycerin solutions, bovine-serum-albumin, and dimethyl sulfoxide.
  • Integration with a smartphone application maintained measurement accuracy while improving usability.

Conclusions:

  • The developed paper-based viscometer provides a simple, cost-effective, and accurate method for blood plasma viscosity measurement.
  • This technology has the potential to significantly enhance clinical diagnostic capabilities by making viscosity analysis more accessible.
  • The combination of paper microfluidics, colorimetric detection, and smartphone integration represents a promising advancement in point-of-care diagnostics.