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Three neglected numbers in the CBC: The RDW, MPV, and NRBC count

Jori E May1, Marisa B Marques2, Vishnu V B Reddy2

  • 1Department of Medicine, University of Alabama, Birmingham, AL, USA. jemay@uabmc.edu.

Cleveland Clinic Journal of Medicine
|March 9, 2019
PubMed

Insights

The complete blood cell count (CBC) offers valuable insights beyond standard measures. This review highlights the diagnostic and prognostic importance of red blood cell distribution width (RDW), mean platelet volume (MPV), and nucleated red blood cells (NRBCs) in CBC testing.

Area of Science:

  • Hematology
  • Clinical Pathology
  • Laboratory Medicine

Background:

  • The complete blood cell count (CBC) is a routine laboratory test.
  • Certain CBC parameters are frequently underutilized in clinical practice.
  • Understanding all CBC components can enhance patient assessment.

Purpose of the Study:

  • To review the diagnostic and prognostic value of underutilized CBC components.
  • To highlight the clinical applications of RDW, MPV, and NRBC counts.
  • To encourage comprehensive interpretation of CBC results.

Main Methods:

  • Literature review of studies on RDW, MPV, and NRBCs.
  • Analysis of diagnostic applications and prognostic implications.
  • Synthesis of information for clinical integration.

Main Results:

  • Red blood cell distribution width (RDW) provides information on red blood cell size variation.
  • Mean platelet volume (MPV) reflects platelet production and function.
  • Nucleated red blood cell (NRBC) counts can indicate bone marrow stress or hematopoietic activity.

Conclusions:

  • RDW, MPV, and NRBC counts offer unique diagnostic and prognostic information.
  • Incorporating these underutilized CBC values can improve patient care.
  • Comprehensive CBC interpretation leads to a better understanding of a patient's condition.

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