Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.2K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Enzymes02:34

Enzymes

94.6K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
94.6K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.4K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.4K
Enzyme Kinetics01:19

Enzyme Kinetics

104.0K
Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
104.0K
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

814
Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
814
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

875
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
875

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gynecological laparoscopic surgery in Pokhara: four years' experience at Charak memorial hospital.

BMC women's health·2026
Same author

A Rare Case of Multilevel Pott's Disease With Coexistent Pulmonary Cavitary Tuberculosis and Neurogenic Bladder.

Cureus·2025
Same author

A Case of Right Middle Lobe Syndrome: A Rare Diagnosis Behind Chronic Pulmonary Symptoms.

Cureus·2025
Same author

Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition.

Journal of experimental & clinical cancer research : CR·2025
Same author

Stroke in a Young Patient Due to Moyamoya Disease.

South Dakota medicine : the journal of the South Dakota State Medical Association·2024
Same author

Images in Medicine: Right Sided Chest and Back Pain in a Young Female.

South Dakota medicine : the journal of the South Dakota State Medical Association·2024
Same journal

2025 Scholars' Research Symposium Abstract: Influence of Disability Education, Panel Discussion on Comfort and Knowledge of Healthcare Providers in South Dakota.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025
Same journal

2025 Scholars' Research Symposium Abstract: Improving Interactions During Medical Interpretation: An Educational Module for Medical Students.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025
Same journal

2025 Scholars' Research Symposium Abstract: Walk With Ease Benefiting South Dakota.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025
Same journal

2025 Scholars' Research Symposium Abstract: Ultrasonographic Accuracy in Rural vs Urban Counties.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025
Same journal

2025 Scholars' Research Symposium Abstract: Minimizing Grief and Loss Through Advanced Care Planning.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025
Same journal

2025 Scholars' Research Symposium Abstract: Food Security During Pregnancy and Adverse Birth Outcomes.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver
10:38

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver

Published on: May 4, 2016

16.2K

Statins and Abnormal Liver Enzymes.

Anup Shrestha1,2, Alex Mulmi3,4, Raiko Munankarmi4

  • 1Internal Medicine Residency Program, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

South Dakota Medicine : the Journal of the South Dakota State Medical Association
|March 9, 2019
PubMed
Summary
This summary is machine-generated.

Statins effectively reduce mortality in cardiovascular diseases but can transiently elevate liver enzymes. This review guides physicians on safely using statins in patients with baseline or treatment-induced liver enzyme elevations.

More Related Videos

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

19.6K
Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

4.0K

Related Experiment Videos

Last Updated: Jan 28, 2026

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver
10:38

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver

Published on: May 4, 2016

16.2K
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

19.6K
Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

4.0K

Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Statins are crucial for managing ischemic heart disease, stroke, and peripheral vascular disease, significantly reducing mortality and morbidity.
  • Transient elevations in liver enzymes are a known side effect of statin therapy.
  • Physicians face challenges prescribing statins to patients with pre-existing or statin-induced liver enzyme abnormalities.

Purpose of the Study:

  • To review current literature and provide guidance on the safe and effective use of statins.
  • To address the clinical dilemma of statin prescription in patients with elevated liver enzymes.

Main Methods:

  • Literature review of existing studies and clinical guidelines.
  • Analysis of data regarding statin efficacy and safety in patients with liver enzyme alterations.

Main Results:

  • Statins are generally safe and effective even with mild liver enzyme elevations.
  • Premature cessation of statins due to transient enzyme increases can be detrimental.
  • Clear guidelines exist for monitoring and managing liver enzymes during statin therapy.

Conclusions:

  • Physicians should not prematurely discontinue statins solely based on transient liver enzyme elevations.
  • Careful patient selection and monitoring allow for the continued use of statins in most patients with elevated liver enzymes.
  • This review aims to support informed clinical decision-making regarding statin therapy.