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Long non-coding SNHG1 in cancer

Khaing Zar Thin1, Jian Cheng Tu2, Sudheesh Raveendran3

  • 1Department of Medical Laboratory Technology, University of Medical Technology, Yankin Hill Road, 19(th) Street, Patheingyi Township, Mandalay, Myanmar; Department & Program of Clinical Laboratory Medicine, Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 9, 2019
PubMed
Abstract

Insights

The long non-coding RNA SNHG1 is upregulated in various cancers and promotes tumor progression. SNHG1 may serve as a valuable biomarker for cancer diagnosis, prognosis, and treatment strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are critical regulators of cellular processes.
  • Aberrant lncRNA expression is implicated in cancer development and progression.
  • SNHG1 is a novel lncRNA with emerging roles in tumorigenesis.

Purpose of the Study:

  • To review current research on the biological functions and mechanisms of SNHG1 in human cancers.
  • To emphasize SNHG1's role in clinical management, tumor progression, and molecular mechanisms.
  • To explore SNHG1 as a potential diagnostic and prognostic biomarker.

Main Methods:

  • Systematic literature search of PubMed, Embase, Google Scholar, and Cochrane Library.
  • Review and synthesis of studies on lncRNA SNHG1's involvement in tumorigenesis.
  • Analysis of SNHG1's association with clinical parameters and cancer cell behavior.

Main Results:

  • SNHG1 is oncogenic and aberrantly expressed in multiple cancers (colorectal, liver, lung, gastric, etc.) and other diseases.
  • Upregulation of SNHG1 correlates with advanced tumor stage, size, TNM stage, and poorer survival.
  • SNHG1 promotes cancer cell proliferation, migration, invasion, and metastasis.

Conclusions:

  • SNHG1 is a significant oncogenic lncRNA in human cancers.
  • SNHG1 expression levels are associated with adverse clinical outcomes.
  • SNHG1 holds potential as a valuable biomarker for cancer diagnosis, prognosis, and therapeutic strategies.
Keywords:
A novel biomarkerLong non-coding RNASNHG1

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