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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Anticancer activity of palladium-based complexes against triple-negative breast cancer

Martin Vojtek1, Maria P M Marques2, Isabel M P L V O Ferreira3

  • 1LAQV/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Drug Discovery Today
|March 9, 2019
PubMed

Insights

Triple-negative breast cancer (TNBC) lacks targeted therapies. This review explores palladium(II) complexes as promising alternatives to platinum drugs, detailing their anticancer activity and potential targets for TNBC treatment.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Nanotechnology

Background:

  • Triple-negative breast carcinoma (TNBC) represents a significant unmet medical need due to its aggressive nature, high metastatic potential, and limited treatment options.
  • Current mainstay therapies, such as platinum chemotherapeutics, face challenges including severe toxicity and acquired resistance, necessitating the exploration of alternative treatments.
  • Palladium(II) complexes are being investigated as potential anticancer agents due to their structural and coordination chemistry similarities to platinum drugs.

Purpose of the Study:

  • To review the current knowledge on palladium(II) complexes for their potential application in treating triple-negative breast carcinoma.
  • To emphasize the anticancer activity and identify putative pharmacological targets of these palladium(II) complexes in TNBC.

Main Methods:

  • Comprehensive literature review of 121 palladium(II) complexes.
  • Analysis of reported anticancer activities against TNBC models.
  • Identification of potential molecular targets and mechanisms of action.

Main Results:

  • Palladium(II) complexes demonstrate significant anticancer activity against TNBC, offering a potential alternative to platinum-based chemotherapy.
  • The review highlights diverse structural motifs and coordination environments within the studied Pd(II) complexes.
  • Several Pd(II) complexes show promise in overcoming resistance mechanisms associated with platinum drugs.

Conclusions:

  • Palladium(II) complexes represent a promising class of metallodrugs for the development of novel targeted therapies for triple-negative breast carcinoma.
  • Further research into their pharmacological targets and clinical efficacy is warranted to translate these findings into effective treatments for TNBC patients.

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