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Related Experiment Videos

[DNA interaction with the antitumor agent thiophosphamide].

G L Piatigorskaia, O Iu Zhilkova, L M Murav'eva

    Molekuliarnaia Biologiia
    |March 1, 1986
    PubMed
    Summary

    This study investigated DNA interaction with the antitumor drug thiotepa (N,N',N"-triethylenethiophosphoramide). Thiotepa binding destabilizes DNA, forming cross-links and causing breaks, with implications for its in vivo efficacy.

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