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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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ARDS in Obese Patients: Specificities and Management.

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This review is part of the Annual Update in Intensive Care and Emergency Medicine 2019, offering insights into critical care advancements. Explore other selected articles for comprehensive emergency medicine knowledge.

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Area of Science:

  • Critical Care Medicine
  • Emergency Medicine
  • Medical Reviews

Background:

  • This article is part of a curated collection from the Annual Update in Intensive Care and Emergency Medicine 2019.
  • It represents one of ten selected reviews from this prominent annual series.

Purpose of the Study:

  • To disseminate key findings and advancements in intensive care and emergency medicine.
  • To provide access to a broader audience through online publication.

Main Methods:

  • Selection of ten high-impact reviews from the Annual Update in Intensive Care and Emergency Medicine 2019.
  • Online compilation of these selected reviews for wider accessibility.

Main Results:

  • A collection of ten expert reviews covering critical care and emergency medicine topics is now available.
  • These reviews offer valuable updates for healthcare professionals.

Conclusions:

  • The selected reviews provide a valuable resource for staying abreast of the latest developments in intensive care and emergency medicine.
  • Access to these articles facilitates continuous professional development in critical care fields.