Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Models02:00

Molecular Models

43.7K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.7K
The Bohr Model02:18

The Bohr Model

80.7K
Following the work of Ernest Rutherford and his colleagues in the early twentieth century, the picture of atoms consisting of tiny dense nuclei surrounded by lighter and even tinier electrons continually moving about the nucleus was well established. This picture was called the planetary model since it pictured the atom as a miniature “solar system” with the electrons orbiting the nucleus like planets orbiting the sun. The simplest atom is hydrogen, consisting of a single proton as the...
80.7K
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

310
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
310
Clearance Models: Compartment Models01:25

Clearance Models: Compartment Models

305
Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume...
305
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

7.1K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
7.1K
Stereotype Content Model02:16

Stereotype Content Model

15.4K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical stress attenuates the metabolic reprogramming and M1 polarization of macrophages by upregulating integrin subunit alpha D.

Cellular signalling·2026
Same author

Exploring the Possible Role of Gut Microbiota with Ischemic Stroke Subtypes: A Mendelian Randomization Study with Insights into Immune Cell Mediators.

Current medicinal chemistry·2026
Same author

Shunaoxin dropping pills alleviate cerebral ischemia-reperfusion injury in MCAO rats associated with ferroptosis inhibition and AKT/Nrf2/HO-1 pathway activation.

Fitoterapia·2026
Same author

Gut microbiota-derived extracellular vesicles: novel perspectives from host-microbe interactions to therapeutic applications.

Journal of physiology and biochemistry·2026
Same author

A Boruta-SMOTE Integrated Approach for Rapid Donkey Breed Classification Using SNP Data: Addressing High-Dimensionality and Small Sample Challenges.

Biochemical genetics·2026
Same author

Systematic Evaluation of Human Plasma Extracellular Vesicle Isolation and Physical Stability by Comparing Ultracentrifugation and Magnetic Bead-Based Methods.

Biopreservation and biobanking·2025

Related Experiment Video

Updated: Jan 28, 2026

The Mouse Cremaster Muscle Preparation for Intravital Imaging of the Microcirculation
07:19

The Mouse Cremaster Muscle Preparation for Intravital Imaging of the Microcirculation

Published on: June 10, 2011

33.0K

A Bidomain Model for Lens Microcirculation.

Yi Zhu1, Shixin Xu2, Robert S Eisenberg3

  • 1Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.

Biophysical Journal
|March 10, 2019
PubMed
Summary
This summary is machine-generated.

This study links early analytical models with modern computational models of eye lens microcirculation. The new simplified model bridges these, aiding research in similar tissues like the brain.

More Related Videos

Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher
05:14

Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher

Published on: February 23, 2018

7.2K
Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window
08:37

Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window

Published on: November 18, 2010

18.0K

Related Experiment Videos

Last Updated: Jan 28, 2026

The Mouse Cremaster Muscle Preparation for Intravital Imaging of the Microcirculation
07:19

The Mouse Cremaster Muscle Preparation for Intravital Imaging of the Microcirculation

Published on: June 10, 2011

33.0K
Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher
05:14

Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher

Published on: February 23, 2018

7.2K
Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window
08:37

Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window

Published on: November 18, 2010

18.0K

Area of Science:

  • Ophthalmology
  • Biophysics
  • Computational Biology

Background:

  • Decades of research exist on mammalian eye lens physiology.
  • Pioneering analytical models were developed in the 1970s and 80s.
  • Recent advancements include complex computational models of eye lens microcirculation.

Purpose of the Study:

  • To bridge early analytical models with recent computational models of eye lens microcirculation.
  • To introduce a general nonelectroneutral model for lens microcirculation.
  • To derive and validate a simplified model based on physiological data.

Main Methods:

  • Development of a general nonelectroneutral model for lens microcirculation.
  • Asymptotic analysis to derive a simplified model.
  • Comparison of the simplified model with existing literature and full computational models.

Main Results:

  • The simplified model connects to first-generation analytical models.
  • The full model aligns with the latest computational models.
  • The simplified model accurately reflects key features of the full computational models.

Conclusions:

  • The derived simplified model serves as a crucial link between analytical and computational approaches.
  • This work facilitates understanding microcirculation in other tissues with narrow extracellular spaces.
  • Simplified models can elucidate system function before complex computational models are feasible.