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Related Experiment Video

Updated: Jan 28, 2026

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

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[Sarcoidosis].

S Salah1, S Abad2, A P Brézin1

  • 1Department of ophthalmology, université Paris Descartes, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.

Journal Francais D'Ophtalmologie
|March 10, 2019
PubMed
Summary
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Sarcoidosis is a systemic inflammatory disease that can affect the eyes, causing granulomatous uveitis. Diagnosis can be challenging, especially when systemic signs are absent, but treatment options are available.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Systemic Inflammatory Diseases

Background:

  • Sarcoidosis is a multisystem granulomatous disease.
  • Ocular involvement, particularly uveitis, occurs in 20-50% of cases.
  • Ocular sarcoidosis diagnosis is challenging due to potential lack of systemic evidence.

Purpose of the Study:

  • To review the diagnosis and management of ocular sarcoidosis.
  • To highlight diagnostic difficulties in isolated ocular cases.
  • To discuss current and alternative treatment strategies.

Main Methods:

  • Review of clinical, paraclinical, and histological findings in sarcoidosis diagnosis.
  • Analysis of diagnostic algorithms for ocular sarcoidosis.
  • Evaluation of treatment responses to corticosteroids and immunosuppressants.
Keywords:
Choroïdite multifocaleEpithelioid and giant cell granulomaGranulomatose systémiqueGranulomatous uveitisGranulome épithélioïde et gigantocellulaireHeerfordt syndromeMikulicz syndromeMultifocal choroiditisPosterior uveitisSyndrome de MikuliczSyndrome d’HeerfordtSystemic granulomatosisUvéite granulomateuseUvéite postérieure

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Last Updated: Jan 28, 2026

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

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Main Results:

  • Ocular sarcoidosis often presents as granulomatous uveitis with retinal vasculitis.
  • Diagnosis is presumed without histology in isolated uveitis cases.
  • Steroids are first-line treatment; methotrexate and anti-TNF-alpha agents are alternatives for refractory cases.

Conclusions:

  • Ocular sarcoidosis diagnosis requires a combination of clinical and systemic findings.
  • Diagnostic algorithms aid in probable cases of isolated ocular sarcoidosis.
  • Effective treatments exist, including steroids, methotrexate, and anti-TNF-alpha therapy.