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Related Experiment Video

Updated: Jan 28, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Brain-responsive neurostimulation for epilepsy (RNS® System).

Tara L Skarpaas1, Beata Jarosiewicz1, Martha J Morrell2

  • 1NeuroPace, Inc., Mountain View, CA, United States.

Epilepsy Research
|March 10, 2019
PubMed
Summary
This summary is machine-generated.

Responsive neurostimulation with the RNS System significantly reduces disabling focal seizures in adults. This epilepsy treatment is safe, well-tolerated, and improves quality of life and cognitive function over time.

Keywords:
Brain-responsive neurostimulationClosed-loopEpilepsyFocal onsetMedically intractable epilepsyNeurostimulationResponsive

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Epilepsy Research

Background:

  • Medically intractable focal epilepsy presents significant treatment challenges.
  • Current therapies often have limitations in efficacy and side effects.

Purpose of the Study:

  • To evaluate the safety and efficacy of the RNS System for treating focal seizures.
  • To assess long-term seizure reduction and impact on quality of life.

Main Methods:

  • Controlled clinical trials involving adults with focal epilepsy.
  • Utilized closed-loop responsive neurostimulation targeting the seizure focus.
  • Chronic ambulatory electrocorticographic monitoring was employed.

Main Results:

  • Significant reduction in disabling seizure frequency, reaching a median of 75% after 9 years.
  • The RNS System demonstrated good tolerability and acceptable safety.
  • Improvements in quality of life and cognitive function were observed.

Conclusions:

  • Responsive neurostimulation is an effective treatment for medically intractable focal seizures.
  • The RNS System offers long-term seizure control and functional benefits.
  • Continuous monitoring provides valuable insights for epilepsy management and research.