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Updated: Jan 28, 2026

Spectral Reflectometric Microscopy on Myelinated Axons In Situ
Published on: July 2, 2018
On a two-truths phenomenon in spectral graph clustering.
Carey E Priebe1,2,3, Youngser Park2, Joshua T Vogelstein2,4
1Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218; cep@jhu.edu.
Spectral graph clustering uses different embedding methods, Laplacian spectral embedding (LSE) and adjacency spectral embedding (ASE), yielding distinct groupings. LSE reveals hemisphere structure, while ASE identifies gray/white matter organization in diffusion MRI connectomes.
Area of Science:
- Graph theory
- Machine learning
- Neuroimaging
Background:
- Spectral graph clustering groups data based on graph structure without predefined labels.
- Commonly uses K-means or Gaussian mixture models with Laplacian spectral embedding (LSE) or adjacency spectral embedding (ASE).
Purpose of the Study:
- To investigate the
- two-truths
- phenomenon in spectral graph clustering, comparing LSE and ASE.
- To illustrate how different spectral embedding methods yield distinct clustering results.
Main Methods:
- Applied spectral graph clustering to a diffusion MRI connectome dataset.
- Utilized both Laplacian spectral embedding (LSE) and adjacency spectral embedding (ASE) for graph vertex clustering.
- Employed K-means clustering on the spectral embeddings.
Main Results:
- Demonstrated that LSE and ASE produce different clustering outcomes.
- LSE effectively captured left vs. right hemisphere structural affinities.
- ASE identified a core-periphery structure related to gray matter and white matter.
Conclusions:
- The choice of spectral embedding method significantly impacts clustering results in graph analysis.
- LSE and ASE capture complementary structural information in diffusion MRI connectomes.
- Understanding these differences is crucial for accurate data interpretation in neuroimaging and other fields.
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