Related Experiment Video

Updated: Jan 28, 2026

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
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Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

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GSAP modulates γ-secretase specificity by inducing conformational change in PS1

Eitan Wong1,2, George P Liao1,3, Jerry C Chang2

  • 1Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Proceedings of the National Academy of Sciences of the United States of America
|March 10, 2019
PubMed

Keywords:
Alzheimer’s diseaseGSAPactive-site labelingconformational changeγ-secretase modulation

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