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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
Published on: September 12, 2025
797
Direct Costs Associated with Relapsed Diffuse Large B-Cell Lymphoma Therapies
Anna Purdum1, Ryan Tieu2, Sheila R Reddy2
1Kite Pharma, Inc., Santa Monica, California, USA apurdum@kitepharma.com.
The Oncologist
|March 10, 2019
Summary
Second-line therapy for diffuse large B-cell lymphoma (DLBCL) significantly increases healthcare costs, driven by treatments like hematopoietic stem cell transplant (HSCT) and chemotherapy. Further research into novel therapies is crucial for better outcomes and cost reduction.
Area of Science:
- Hematology
- Oncology
- Health Economics
Background:
- Diffuse large B-cell lymphoma (DLBCL) has a significant relapse rate after first-line therapy.
- Second-line (2L) treatment is crucial for patients who relapse but represents a substantial healthcare burden.
Purpose of the Study:
- To analyze healthcare utilization and associated costs for DLBCL patients receiving 2L therapy compared to those who did not relapse.
- To identify key cost drivers in the 2L DLBCL treatment landscape.
Main Methods:
- Retrospective analysis of claims data (2006-2015) for DLBCL patients.
- Comparison of patients receiving 2L therapy versus 'cured' controls.
- Subgroup analysis based on hematopoietic stem cell transplant (HSCT) and time to relapse.
Main Results:
- 2L patients incurred significantly higher 1- and 2-year healthcare costs compared to controls ($210,488 vs. $25,044 in Year 1).
- Hematopoietic stem cell transplant (HSCT) and chemotherapy were major cost contributors for 2L patients.
- 2L patients had a higher comorbidity index and mortality risk.
Conclusions:
- Diffuse large B-cell lymphoma (DLBCL) treatment, especially 2L therapy, is resource-intensive.
- Hematopoietic stem cell transplant (HSCT) may be underutilized, and chemotherapy regimens lack consensus.
- Development of novel, effective therapies is needed to improve survival and reduce costs.
Keywords:
Diffuse large B‐cell lymphomaDrug therapyHealth care costsHematopoietic stem cell transplantInsurance claim reviewRetrospective studiesMore Related Videos
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