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Updated: Jan 28, 2026

Super-resolution Imaging of Neuronal Dense-core Vesicles
Published on: July 2, 2014
Deep learning-based super-resolution in coherent imaging systems
Tairan Liu1,2,3, Kevin de Haan1,2,3, Yair Rivenson1,2,3
1Electrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.
Abstract:
We present a deep learning framework based on a generative adversarial network (GAN) to perform super-resolution in coherent imaging systems. We demonstrate that this framework can enhance the resolution of both pixel size-limited and diffraction-limited coherent imaging systems. The capabilities of this approach are experimentally validated by super-resolving complex-valued images acquired using a lensfree on-chip holographic microscope, the resolution of which was pixel size-limited. Using the same GAN-based approach, we also improved the resolution of a lens-based holographic imaging system that was limited in resolution by the numerical aperture of its objective lens. This deep learning-based super-resolution framework can be broadly applied to enhance the space-bandwidth product of coherent imaging systems using image data and convolutional neural networks, and provides a rapid, non-iterative method for solving inverse image reconstruction or enhancement problems in optics.
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