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Amplicon Sequencing using the Long-Read Sequencing Technologies
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Pierre Robin Sequence.

Sun T Hsieh1, Albert S Woo2

  • 1Department of Plastic Surgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 2 Dudley Street, Suite 500, Providence, RI 02905, USA.

Clinics in Plastic Surgery
|March 11, 2019
PubMed
Summary
This summary is machine-generated.

Pierre Robin sequence involves micrognathia, glossoptosis, and airway compromise. Management requires a multidisciplinary approach, starting with conservative measures and progressing to surgical interventions if needed.

Keywords:
Cleft palateDistractionGlossoptosisMicrognathiaPierre Robin sequence

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Area of Science:

  • Pediatric Otolaryngology
  • Craniofacial Anomalies
  • Sleep Medicine

Background:

  • Pierre Robin sequence is characterized by a triad of micrognathia, glossoptosis, and airway compromise, often with a cleft palate.
  • High incidence of syndromic associations necessitates a comprehensive evaluation.
  • Airway obstruction and feeding difficulties are primary concerns.

Purpose of the Study:

  • To outline the diagnostic methods for evaluating airway obstruction in Pierre Robin sequence.
  • To describe the range of management strategies, from conservative to surgical.
  • To emphasize the importance of a multidisciplinary approach.

Main Methods:

  • Clinical assessment including physical examination.
  • Polysomnography to identify obstructive events.
  • Nasoendoscopy and bronchoscopy for detailed airway inspection.

Main Results:

  • Nonsurgical options include prone positioning, nasopharyngeal stenting, and continuous positive airway pressure.
  • Surgical interventions comprise mandibular distraction and tongue-lip adhesion.
  • Tracheostomy is indicated for subglottic obstruction and central sleep apnea.

Conclusions:

  • Effective management of Pierre Robin sequence hinges on early diagnosis and a coordinated, multidisciplinary team.
  • A stepwise approach, beginning with conservative treatments, is crucial.
  • Timely surgical intervention and airway support are vital for optimal outcomes.