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Taking SCLC on a Bad LSD(1) Trip One NOTCH Further

Jun Kim1, Julien Sage1

  • 1Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Trends in Molecular Medicine
|March 11, 2019
PubMed

Insights

Inhibition of LSD1 demethylase may treat small cell lung cancer (SCLC). This approach activates the NOTCH pathway, potently suppressing SCLC tumor growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Small cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic strategies.
  • The LSD1 demethylase enzyme plays a critical role in SCLC progression.

Discussion:

  • A study by Augert et al. demonstrates that inhibiting LSD1 demethylase in SCLC cells leads to the derepression of NOTCH receptor genes.
  • This derepression results in the activation of the NOTCH signaling pathway.

Key Insights:

  • LSD1 inhibition effectively suppresses SCLC tumor growth.
  • The NOTCH pathway is a key mediator of the anti-cancer effects of LSD1 inhibition in SCLC.

Outlook:

  • Targeting LSD1 demethylase represents a promising therapeutic strategy for SCLC.
  • Further research into NOTCH pathway activation could yield novel SCLC treatments.
Keywords:
ASCL1LSD1NOTCHSCLCepigeneticsneuroendocrine

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