Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.1K
Human Genetics01:28

Human Genetics

1.6K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.6K
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K
Genetics of Speciation02:16

Genetics of Speciation

21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K
Personal Identity01:25

Personal Identity

352
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
352

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-orchestrated design-build-test-learn is the future of mammalian biodesign.

Nature biomedical engineering·2026
Same author

Optical UVA biosensor platform for high-throughput testing of UV blockers.

The Journal of investigative dermatology·2026
Same author

Self-driving medicine: closed-loop therapeutics for autonomous disease control.

Trends in biotechnology·2026
Same author

A synthetic angiotensin II/ACE2-based hormone shunt controlling experimental hypertension.

Nature communications·2026
Same author

Next-generation programmable cell therapies for precision medicine.

Nature reviews. Genetics·2026
Same author

Traceless Regulation of Genetic Circuitry.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Related Experiment Video

Updated: Jan 28, 2026

Viral Tracing of Genetically Defined Neural Circuitry
13:06

Viral Tracing of Genetically Defined Neural Circuitry

Published on: October 17, 2012

19.1K

Genetic circuitry for personalized human cell therapy.

Fabian Tolle1, Pascal Stücheli1, Martin Fussenegger2

  • 1Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.

Current Opinion in Biotechnology
|March 11, 2019
PubMed
Summary

Synthetic biology engineers cells with gene circuits to precisely control gene expression. These designer cells offer promising new therapeutic options for personalized medicine, especially where traditional treatments fall short.

More Related Videos

Isolation and Culture of Human Adipose-Derived Stem Cells With an Innovative Xenogeneic-Free Method for Human Therapy
06:00

Isolation and Culture of Human Adipose-Derived Stem Cells With an Innovative Xenogeneic-Free Method for Human Therapy

Published on: February 3, 2023

4.1K
Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
10:28

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Published on: April 3, 2021

7.1K

Related Experiment Videos

Last Updated: Jan 28, 2026

Viral Tracing of Genetically Defined Neural Circuitry
13:06

Viral Tracing of Genetically Defined Neural Circuitry

Published on: October 17, 2012

19.1K
Isolation and Culture of Human Adipose-Derived Stem Cells With an Innovative Xenogeneic-Free Method for Human Therapy
06:00

Isolation and Culture of Human Adipose-Derived Stem Cells With an Innovative Xenogeneic-Free Method for Human Therapy

Published on: February 3, 2023

4.1K
Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
10:28

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Published on: April 3, 2021

7.1K

Area of Science:

  • Synthetic biology
  • Genetic engineering
  • Systems biology

Background:

  • Synthetic biology applies engineering principles to biological systems.
  • Complex gene circuits enable precise control over gene expression.
  • Designer cells can be programmed for specific responses.

Purpose of the Study:

  • To highlight recent advancements in designer cells for personalized medicine.
  • To showcase engineered gene circuits for therapeutic applications.
  • To demonstrate the potential of synthetic biology in healthcare.

Main Methods:

  • Engineering synthetic gene switches and circuits.
  • Designing gene circuitry for sensing and integration of signals.
  • Developing designer cells for targeted therapeutic protein production.

Main Results:

  • Engineered gene circuits allow precise spatiotemporal control of gene expression.
  • Designer cells can react to pre-programmed conditions and trigger responses.
  • Demonstrated potential for therapeutic protein production.

Conclusions:

  • Designer cells with advanced gene circuitry represent a promising therapeutic modality.
  • These engineered cells offer novel solutions for personalized human medicine.
  • Synthetic biology advancements are expanding therapeutic possibilities beyond traditional treatments.