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Leukemoid reaction associated with severe diabetic ketoacidosis
Southern Medical Journal
|May 1, 1986
Summary
A severe case of diabetic ketoacidosis (DKA) in a 30-year-old man was unexpectedly accompanied by a leukemoid reaction. This reaction resolved with standard DKA treatment, suggesting it can occur without underlying malignancy or infection.
Area of Science:
- Endocrinology
- Hematology
Background:
- Diabetic ketoacidosis (DKA) is a serious complication of diabetes mellitus.
- Leukemoid reactions, characterized by elevated white blood cell counts, are typically associated with underlying infections or malignancies.
Observation:
- A 30-year-old male patient presented with severe diabetic ketoacidosis.
- The patient also exhibited a leukemoid reaction, presenting as a significantly elevated white blood cell count.
Findings:
- The leukemoid reaction resolved completely following standard treatment for DKA, including intravenous fluids and insulin.
- No evidence of an underlying malignancy or infection was found in the patient.
Implications:
- This case suggests that a leukemoid reaction can be an unusual manifestation of uncomplicated diabetic ketoacidosis.
- Further research may be warranted to understand the mechanisms linking DKA and leukemoid reactions.