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Circulating Long Non-coding RNA ENST00000507296 Is a Prognostic Indicator in Patients with Dilated Cardiomyopathy

Xudong Zhang1, Xiang Nie1, Shuai Yuan1

  • 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan, China.

Molecular Therapy. Nucleic Acids
|March 11, 2019
PubMed

Insights

Circulating long non-coding RNA ENST00000507296 shows promise as a prognostic biomarker for dilated cardiomyopathy (DCM). Lower levels of this biomarker correlate with improved event-free survival in DCM patients, aiding in disease management.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Long non-coding RNAs (lncRNAs) are implicated in cardiovascular disease pathogenesis.
  • The utility of circulating lncRNAs as biomarkers for dilated cardiomyopathy (DCM) remains largely unexplored.

Purpose of the Study:

  • To investigate the potential of circulating lncRNAs as diagnostic and prognostic biomarkers for DCM.
  • To identify specific lncRNAs associated with DCM and its severity.

Main Methods:

  • Microarray profiling and real-time qPCR were used to screen and validate lncRNAs in controls and DCM patients.
  • lncRNA sequencing in heart-derived cells explored potential origins.
  • Receiver-operating characteristic (ROC) curve analysis assessed diagnostic accuracy.
  • Cox regression and Kaplan-Meier analyses evaluated prognostic value.

Main Results:

  • Eight candidate lncRNA biomarkers were identified, with five validated in a second cohort.
  • Circulating lncRNA ENST00000507296 levels correlated significantly with cardiac function.
  • Lower levels of ENST00000507296 were associated with higher event-free survival in DCM patients.

Conclusions:

  • Circulating lncRNA ENST00000507296 serves as a valuable prognostic biomarker for patients with DCM.
  • This finding supports the potential use of ENST00000507296 in monitoring DCM progression and patient outcomes.
Abstract

Keywords:
circulating long non-coding RNAsdilated cardiomyopathyprognosis

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