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Updated: Jan 28, 2026
06:08
Formulating and Characterizing an Exosome-based Dopamine Carrier System
Published on: April 4, 2022
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Dopamine Agonists: From the 1970s to Today
Renata S Auriemma1, Rosa Pirchio1, Dario De Alcubierre1
1Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
Neuroendocrinology
|March 11, 2019
Summary
Dopamine agonists effectively treat prolactinomas by normalizing prolactin levels and restoring hormonal balance. This therapy has significantly advanced the management of these pituitary tumors since the 1970s.
Area of Science:
- Endocrinology
- Neuroendocrinology
- Oncology
Background:
- Dopamine inhibits prolactin secretion.
- Prolactinomas are pituitary tumors that secrete prolactin.
- Dopaminergic therapy has revolutionized prolactinoma treatment.
Purpose of the Study:
- To provide an overview of dopamine agonist evolution.
- To discuss their use in PRL-secreting pituitary tumors.
- To highlight treatment outcomes.
Main Methods:
- Literature review of dopamine agonists.
- Analysis of their application in prolactinoma management.
- Historical perspective from the 1970s to present.
Main Results:
- Dopamine agonists normalize prolactin (PRL) levels in most patients.
- Treatment restores eugonadism.
- Tumor mass reduction is commonly achieved.
Conclusions:
- Dopamine agonists are highly effective for PRL-secreting pituitary tumors.
- They offer comprehensive management including hormonal normalization and tumor shrinkage.
- Long-term success in the majority of patients is achievable.
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