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Related Experiment Videos

Accuracy of gas analysis in lung function laboratories.

D J Chinn, Y Naruse, J E Cotes

    Thorax
    |February 1, 1986
    PubMed
    Summary

    Analytical standards in lung function laboratories have declined. Accuracy for gas analysis (carbon monoxide, helium, oxygen, carbon dioxide) was poor, with wide interlaboratory variations impacting crucial lung function measurements.

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    Area of Science:

    • Pulmonary Physiology
    • Medical Diagnostics
    • Analytical Chemistry

    Background:

    • Lung function laboratories rely on accurate gas analysis for diagnostic testing.
    • Previous studies indicated established analytical standards for pulmonary function tests.
    • Recent advancements in instrumentation suggest potential for improved accuracy.

    Purpose of the Study:

    • To assess the current analytical accuracy and interlaboratory variability in lung function testing.
    • To identify sources of error in the analysis of key respiratory gases.
    • To compare current analytical standards with those from two decades prior.

    Main Methods:

    • Fifty lung function laboratories in England and Wales analyzed standardized gas mixtures.
    • Analysis included carbon monoxide, helium, oxygen, and carbon dioxide concentrations.
    • Accuracy, interlaboratory variation, and calibration issues were evaluated.

    Main Results:

    • Percentage accuracy within 1% was achieved in only 14% (CO), 28% (CO2), 37% (He), and 48% (O2) of determinations.
    • Interlaboratory coefficients of variation ranged from 3% (He) to 9% (CO2), impacting calculated lung function values.
    • Calibration errors, including zero errors and curvilinear responses, were identified as significant sources of analytical inaccuracy.

    Conclusions:

    • Current analytical standards in lung function laboratories show a concerning deterioration compared to 20 years ago.
    • Widespread inaccuracies in gas analysis compromise the reliability of lung function measurements.
    • Urgent improvements in analyser calibration and analytical protocols are necessary to restore diagnostic accuracy.

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