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The association between hepatitis and osteoporosis: a nested case-control study using a national sample cohort
Chanyang Min1,2,3, Woo Jin Bang4, Miyoung Kim5
1Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, South Korea.
Archives of Osteoporosis
|March 11, 2019
Summary
Hepatitis B virus infection is linked to a higher risk of osteoporosis, particularly in women. Hepatitis C showed no significant association with osteoporosis in this study.
Area of Science:
- Medical Research
- Epidemiology
- Bone Health
Background:
- Chronic liver diseases, including hepatitis B and C, have been anecdotally linked to osteoporosis.
- Previous studies on this association have yielded inconsistent and insufficient evidence.
- This study aimed to clarify the relationship between hepatitis B/C and osteoporosis.
Purpose of the Study:
- To evaluate the association between hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and osteoporosis.
- To investigate potential differences in this association based on sex and age.
Main Methods:
- A large-scale cohort study using the Korean National Health Insurance Service-National Sample Cohort (2002-2013).
- Inclusion of participants aged 50 and above, with 68,492 osteoporosis patients and an equal number of matched controls.
- Logistic regression analysis was employed to determine adjusted odds ratios, with subgroup analyses by age and sex.
Main Results:
- Osteoporosis patients had a significantly higher adjusted odds ratio for hepatitis B (aOR=1.19, P<0.001).
- No significant association was found between osteoporosis and hepatitis C (aOR=1.04, P>0.05).
- Subgroup analysis revealed a higher risk of hepatitis B in female osteoporosis patients, but not in males.
Conclusions:
- Hepatitis B virus infection may be a contributing risk factor for developing osteoporosis.
- The association between hepatitis B and osteoporosis appears to be more pronounced in females.
- Hepatitis C does not appear to be significantly associated with osteoporosis in this population.
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