Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.4K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.4K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

989
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
989
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K
Blind Procedures02:07

Blind Procedures

13.4K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.4K
Handwashing II: Pre-procedure and Initial Procedure Steps01:19

Handwashing II: Pre-procedure and Initial Procedure Steps

1.5K
The pre-procedure steps of handwashing include removing jewelry and rolling up sleeves. However, many organizations allow staff to wear wedding rings.
The hand washing procedure itself includes the following steps. First, cover cuts, if any, on hands with a waterproof dressing. Cuts and abrasions can become contaminated with bacteria hindering the ability to clean the area thoroughly. In addition, repeated hand washing can worsen an injury.  The nails must be short and clean, without nail...
1.5K
Handwashing III: During the Procedure and Post-Procedure Steps01:15

Handwashing III: During the Procedure and Post-Procedure Steps

2.2K
To wash hands properly, follow these steps:
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of and risk factors for diabetic retinopathy: The Thessaloniki Eye Study.

Eye (London, England)·2026
Same author

The Genomic Landscape of MYC, MYCL, and MYCN Amplified Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Vision Impairment, Insurance Coverage, and Out-of-Pocket Spending.

JAMA network open·2026
Same author

Discontinuation of combo immunotherapy and outcome of patients with melanoma brain metastases.

Journal for immunotherapy of cancer·2026
Same author

YIA26-003: Characterizing the Peripheral T-Cell Repertoire in Patients With Unresectable Melanoma Treated With the IDO- and PD-L1 Targeted Peptide Vaccine IO102-IO103 and Nivolumab-Relatlimab Fixed-Dose Combination.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Baseline risk factors for the development of open-angle glaucoma in a 12-year glaucoma incidence study: the Thessaloniki Eye Study.

The British journal of ophthalmology·2026

Related Experiment Video

Updated: Jan 28, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.6K

Cyclodestructive procedures for refractory glaucoma.

Monica F Chen1, Carole H Kim, Anne L Coleman

  • 1Stein Eye Institute, UCLA, 100 Stein Plaza, Los Angeles, California, USA, 90095.

The Cochrane Database of Systematic Reviews
|March 11, 2019
PubMed
Summary
This summary is machine-generated.

Cyclodestructive procedures for refractory glaucoma show inconclusive results compared to other treatments. Further research is needed to determine the best methods and their safety, as hypotony and phthisis bulbi were common adverse events.

More Related Videos

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.7K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K

Related Experiment Videos

Last Updated: Jan 28, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.6K
Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.7K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Intraocular Pressure Management

Background:

  • Cyclodestructive procedures are utilized for refractory glaucoma when filtration surgeries and medical therapies fail to lower intraocular pressure (IOP).
  • These procedures reduce IOP by decreasing aqueous humor formation through ciliary body destruction.
  • Laser cyclophotocoagulation (CPC) and endoscopic cyclophotocoagulation (ECP) are common cyclodestructive techniques, with ongoing debate on their comparative efficacy.

Purpose of the Study:

  • To evaluate the relative effectiveness and safety of cyclodestructive procedures against other glaucoma treatments.
  • To compare the effectiveness and safety of different individual cyclodestructive procedures against each other.

Main Methods:

  • Inclusion of randomized controlled trials (RCTs) and quasi-RCTs for secondary glaucoma procedures.
  • Searched multiple databases including Cochrane CENTRAL, MEDLINE, Embase, PubMed, LILACS, ClinicalTrials.gov, and WHO ICTRP up to September 21, 2018.
  • Data extraction and risk of bias assessment performed independently by two reviewers.

Main Results:

  • Five trials involving 330 eyes were included; risk of bias was low in one study and unclear in others.
  • Endoscopic cyclophotocoagulation (ECP) versus Ahmed implant showed no significant difference in IOP at 12 months, with very low-certainty evidence suggesting potentially better visual acuity with ECP at 24 months.
  • Comparisons between micropulse and continuous-wave CPC, diode vs. Nd:YAG laser CPC, and different Nd:YAG laser energy levels yielded inconclusive or low-certainty evidence regarding IOP, visual acuity, and medication use. Common adverse events included hypotony and phthisis bulbi.

Conclusions:

  • Evidence is inconclusive regarding the superiority of cyclodestructive procedures over other glaucoma treatments or among different cyclodestructive methods.
  • Hypotony and phthisis bulbi were the most frequently reported adverse events across the included studies.
  • Need for large, well-designed RCTs is emphasized, incorporating patient-reported outcomes like pain and quality of life.