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Yu L Begrambekova1, N A Karanadze, Ya A Orlova

  • 1Lomonosov Moscow State University Medical Research and Educational Center.. fake@neicon.ru.

Kardiologiia
|March 12, 2019
PubMed
Summary

This review explores how respiratory system pathologies develop in congestive heart failure (CHF) patients. It highlights periodic respiration, pulmonary hypertension, and muscle remodeling, plus chemoreceptor and metaboreflex roles in worsening CHF.

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Area of Science:

  • Cardiology
  • Pulmonology
  • Physiology

Background:

  • Congestive heart failure (CHF) is frequently associated with respiratory system pathologies.
  • Understanding these respiratory complications is crucial for managing CHF patients.

Purpose of the Study:

  • To review the mechanisms underlying respiratory system pathology in CHF.
  • To elucidate the role of chemoreceptors and metaboreflex in CHF exacerbation.

Main Methods:

  • Literature review of mechanisms of respiratory system pathology in CHF.
  • Analysis of the role of chemoreceptors and baroreceptors.
  • Discussion of respiratory muscle metaboreflex in CHF.

Main Results:

  • Key mechanisms include periodic respiration, pulmonary hypertension from left heart pathology, and respiratory muscle remodeling.
  • Chemo- and baroreceptors in the carotid zone play a significant role.
  • Hyperactivation of the respiratory muscle metaboreflex contributes to respiratory pathology and CHF exacerbation.

Conclusions:

  • Respiratory system pathologies are integral to CHF development and progression.
  • Targeting chemoreceptor and metaboreflex pathways may offer therapeutic strategies for CHF.

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