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O P Rotar1, A S Alieva, M A Boiarinova

  • 1Almazov National Medical Research Centre.. rotar@almazovcentre.ru.

Kardiologiia
|March 12, 2019
PubMed
Summary
This summary is machine-generated.

The ASCORE calculation method is more sensitive for detecting early vascular aging than the VaSera instrumental method, especially in patients with high blood pressure. This approach aids in cardiovascular risk stratification and patient adherence.

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Area of Science:

  • Cardiology
  • Vascular Health
  • Preventive Medicine

Background:

  • Arterial pressure (AP) above 130/80 mm Hg in individuals without prior cardiovascular events necessitates methods for assessing vascular age.
  • Early detection of vascular aging is crucial for cardiovascular risk stratification and management.

Purpose of the Study:

  • To compare the effectiveness of calculated (ASCORE) versus instrumental (VaSera) methods in estimating vascular age and detecting early vascular aging.
  • To evaluate the concordance between different vascular age estimation methods in a population sample.

Main Methods:

  • A population sample of 477 individuals (aged 40-65) with AP >130/80 mm Hg and no history of cardiovascular events, diabetes, or chronic kidney disease was studied.
  • Vascular age was determined using the ASCORE calculation scale and the VaSera device (cardio-ankle vascular index).

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  • Standard anthropometry, blood lipid, glucose, creatinine, and urine albumin levels were measured.

    • Main Results:

    • The concordance between calculated and instrumental methods for vascular age and early vascular aging was low (κ = 0.099).
    • The ASCORE method detected early vascular aging more frequently than the VaSera device, particularly with elevated cardiovascular risk and in cases of uncontrolled AP.
    • Signs of early vascular aging were more often identified by ASCORE calculation compared to VaSera when target AP levels were not achieved.

    Conclusions:

    • Vascular age estimation, particularly using the ASCORE method, can be an effective tool for physician-led cardiovascular risk stratification and improving patient adherence.
    • The ASCORE method appears more sensitive for detecting premature vascular aging and requires fewer resources than instrumental methods.
    • Early vascular aging syndrome detection is vital, especially for younger individuals with a family history of cardiovascular disease.