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Central Sleep Apnea With Sodium Oxybate in a Pediatric Patient

Arezou Heshmati1

  • 1Columbia University Medical Center, New York, New York.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|March 12, 2019
PubMed

Insights

Sodium oxybate (SO) treatment in a child with narcolepsy type 1 was associated with central apneas. Further research is needed to confirm this link in pediatric patients.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Pediatric Pulmonology

Background:

  • Narcolepsy type 1 is a chronic neurological disorder.
  • Sodium oxybate (SO) is a medication used to manage narcolepsy symptoms.

Observation:

  • A 12-year-old patient with narcolepsy type 1 developed central apneas after receiving SO.
  • Polysomnography revealed central apneas occurring approximately 1.5 hours after the initial SO dose.

Findings:

  • The patient experienced an apnea-hypopnea index of 4.3 events/h, exclusively central apneas.
  • A reduced second dose of SO led to fewer, milder breathing abnormalities, not meeting apnea criteria.

Implications:

  • This case suggests a potential association between SO and central apnea development in pediatric narcolepsy patients.
  • Further polysomnographic studies are warranted to investigate this association in the pediatric population.

Keywords:
central sleep apneanarcolepsy type 1pediatric narcolepsysodium oxybate

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