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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Transfusion-Associated Circulatory Overload: A Clinical Perspective.

Joachim J Bosboom1, Robert B Klanderman2, Yazan Migdady3

  • 1Department of Anaesthesiology, Amsterdam UMC, Amsterdam, Netherlands.

Transfusion Medicine Reviews
|March 12, 2019
PubMed
Summary

Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion complications. This review details TACO

Keywords:
Critical careHematologyHemovigilanceTransfusionVolume overload

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Area of Science:

  • Transfusion Medicine
  • Critical Care Medicine
  • Pulmonary Medicine

Background:

  • Transfusion-associated circulatory overload (TACO) is a significant transfusion complication, recognized for 30 years.
  • TACO is the primary cause of transfusion-related morbidity and mortality globally, affecting 1-12% of at-risk individuals.
  • The pathophysiology of TACO remains incompletely understood, but it is characterized by acute pulmonary edema from circulatory overload within 6-12 hours post-transfusion.

Purpose of the Study:

  • To provide a comprehensive clinical review of TACO.
  • To analyze TACO's pathogenesis, risk factors, clinical presentation, diagnostics, and treatment.
  • To guide clinicians in early detection and intervention for improved patient outcomes.

Main Methods:

  • Critical analysis of existing literature, including large observational cohort studies.
  • Review of pathogenesis, risk factors, clinical presentation, diagnostic modalities, and treatment options.
  • Synthesis of current knowledge to inform clinical practice.

Main Results:

  • Recent studies have enhanced understanding of transfusion risk factors associated with TACO development.
  • The review critically examines the multifaceted aspects of TACO, from cause to management.
  • Insights into volume kinetics and endothelial barrier function are crucial for future research.

Conclusions:

  • Early detection and intervention are key to improving clinical outcomes for TACO.
  • Further research into TACO's pathogenesis is essential for advancing treatment strategies.
  • Understanding volume kinetics and endothelial barrier function will be critical for future progress.