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Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
Published on: June 2, 2020
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Immune Cell-Derived Extracellular Vesicles - Functions and Therapeutic Applications
Rosanne E Veerman1, Gözde Güçlüler Akpinar1, Maria Eldh2
1Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, SE-171 64, Stockholm, Sweden; These authors have contributed equally to this work.
Trends in Molecular Medicine
|March 12, 2019
Summary
Extracellular vesicles (EVs) transfer molecules between cells and are explored for disease treatment. This review focuses on immune cell-derived EVs for potential immunotherapy applications.
Area of Science:
- Immunology
- Cell Biology
- Biotechnology
Background:
- Extracellular vesicles (EVs) are nano-sized vesicles released by all cells, mediating intercellular communication.
- EVs encompass exosomes, microvesicles, and apoptotic bodies, carrying nucleic acids, proteins, and lipids.
- EVs are investigated as biomarkers and therapeutic agents, with FDA-approved assays available.
Purpose of the Study:
- To review the current understanding of immune cell-derived exosomes and microvesicles.
- To discuss the potential of these EVs in immunotherapy strategies.
Main Methods:
- Literature review of studies on immune cell-derived EVs.
- Analysis of EV functions in immune responses and disease.
- Exploration of therapeutic applications in immunotherapy.
Main Results:
- Immune cell-derived EVs play critical roles in immune regulation and cell-to-cell communication.
- EVs can modulate immune responses, making them promising for immunotherapy.
- Clinical trials are investigating EV applications in cancer, graft-versus-host disease, and neurodegenerative diseases.
Conclusions:
- Immune cell-derived EVs offer significant potential for developing novel immunotherapies.
- Further research into EV functions and engineering is crucial for clinical translation.
- EV-based therapies represent a promising frontier in treating various diseases.
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