Relationship between glucose control, glycemic variability, and oxidative stress in children with type 1 diabetes
Natalia Colomo1, Juan Pedro López-Siguero2, Isabel Leiva2
1Servicio de Endocrinología y Nutrición, Hospital Regional de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Plaza del Hospital Civil sn, 29009 Málaga, Spain; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III, C/Sinesio Delgado 4, 28029 Madrid, Spain.
Insights
This study found that in children with type 1 diabetes mellitus (T1DM), higher glucose variability and HbA1c levels correlate with increased oxidative stress markers during daily life. Further research is needed to confirm these findings and their long-term health implications.
Area of Science:
- Pediatric Endocrinology
- Metabolic Disorders
- Biomarkers of Oxidative Stress
Background:
- Limited research exists on the link between oxidative stress and glycemic variability in pediatric type 1 diabetes mellitus (T1DM).
- Previous studies have often reported non-significant associations, highlighting a gap in understanding this relationship.
Purpose of the Study:
- To investigate the correlation between glucose control, glycemic variability, and oxidative stress in children with T1DM.
- To measure oxidative stress using urinary 8-iso-prostanglandin F2-alpha (8-iso-PGF2α) excretion.
Main Methods:
- A cross-sectional study involving 25 children with T1DM was conducted over five days in two settings: a summer camp and their home environment.
- Data collected included daily capillary blood glucose measurements, HbA1c levels, and 24-hour urine samples for 8-iso-PGF2α analysis.
- Calculated glucose variability parameters included standard deviation, coefficient of variation, and mean amplitude of glycemic excursions (MAGE).
Main Results:
- No significant differences in urinary 8-iso-PGF2α levels or glycemic control/variability parameters were observed between the summer camp and home settings.
- During daily life at home, significant positive correlations were found between urinary 8-iso-PGF2α and HbA1c, mean blood glucose (MBG), standard deviation, and MAGE.
- No significant correlations were found during the summer camp phase.
Conclusions:
- A significant association exists between glycemic variability, HbA1c levels, and oxidative stress markers in children with T1DM during their routine daily activities.
- These findings suggest a potential link between day-to-day glucose fluctuations and oxidative stress in this pediatric population.
- Further research is warranted to validate these results and explore the long-term health consequences.
Introduction:
Few studies assessing the relationship between oxidative stress and glycemic variability in children with type 1 diabetes mellitus (T1DM) are available, and most of them reported no significant results.
Objective:
To assess the relationship between glucose control, glycemic variability, and oxidative stress as measured by urinary excretion of 8-iso-prostanglandin F2-alpha (8-iso-PGF2α) in children with T1DM.
Materials And Methods:
A cross-sectional study including 25 children with T1DM. Participants were evaluated during five days in two different situations: 1st phase during a summer camp, and 2nd phase in their everyday life at home. The following data were collected in each study phase:. - Six capillary blood glucose measurements per day. Mean blood glucose (MBG) levels and glucose variability parameters, including standard deviation, coefficient of variation, and mean amplitude of glycemic excursions (MAGE), were calculated. - Capillary HbA1c level. - 24-h urine sample to measure 8-iso-PGF2α.
Results:
There were no statistically significant differences in urinary 8-iso-PGF2α levels (142±37 vs. 172±61pg/mg creatinine) and glucose control and glycemic variability parameters between both phases. In the 2nd phase, statistically significant correlations were found between urinary 8-iso-PGF2α and HbA1c levels (r=0.53), MBG (r=0.72), standard deviation (r=0.49), and MAGE (r=0.42). No significant correlations between glucose control, glycemic variability and urinary 8-iso-PGF2α excretion were found in the 1st phase.
Conclusions:
A significant correlation was found between glycemic variability and HbA1c level and urinary 8-iso-PGF2α excretion in a group of children with T1DM during their daily lives. Additional studies are needed to confirm this finding and to explore its long-term impact on health.
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