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Molecular Evolution of the Tre Recombinase
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FGF23: Clinical usefulness and analytical evolution.

Charlotte Fauconnier1, Tatiana Roy2, Gaëlle Gillerot3

  • 1Department of Laboratory Medicine, Cliniques Universitaires St-Luc, Université Catholique de Louvain, Brussels, Belgium.

Clinical Biochemistry
|March 12, 2019
PubMed
Summary
This summary is machine-generated.

Fibroblast Growth Factor 23 (FGF23) is crucial for phosphate balance and cardiovascular health in kidney disease. Standardizing FGF23 assays is needed for reliable clinical use and improved patient outcomes.

Keywords:
BiomarkerCardiovascular riskFGF23Heart failureKidney diseasesKlothoPhosphate

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Area of Science:

  • Biochemistry
  • Nephrology
  • Cardiology

Background:

  • Fibroblast Growth Factor 23 (FGF23) is a key hormone regulating phosphate homeostasis.
  • FGF23 shows strong correlations with cardiovascular disease biomarkers in chronic kidney disease (CKD) and heart failure (HF) patients.
  • FGF23 is an early marker in CKD and provides prognostic information in both CKD and HF.

Purpose of the Study:

  • To review the clinical significance of FGF23 in nephrology and cardiology.
  • To discuss the challenges and recent advancements in FGF23 assay methodologies.
  • To highlight the need for assay harmonization and standardization.

Main Methods:

  • Review of existing literature on FGF23.
  • Analysis of different FGF23 assay types (intact vs. fragments).
  • Discussion of automated platforms and inter-assay harmonization issues.

Main Results:

  • FGF23 is a valuable biomarker in CKD and HF, offering early detection and prognostic insights.
  • Automated FGF23 assays on multianalyzer platforms offer efficiency but lack standardization.
  • Significant discrepancies exist between different FGF23 assays, impacting clinical utility.

Conclusions:

  • Standardization of FGF23 measurements, potentially through certified reference materials, is essential for clinical application.
  • Further understanding of FGF23's pathophysiology may reveal new therapeutic targets for CKD and HF.
  • Harmonized FGF23 assays will improve diagnostic accuracy and patient management.