Lipofuscin accumulation in the human spleen with an unusual distribution. A case report

Lipofuscin granules were found in an unusual distribution in an atrophic human spleen. The pigment was confined to the sinus littoral cells and was absent from the splenic histiocytes. The lipofuscin differed from the ceroid-type of lipofuscin found in the various conditions associated with the 'syndrome of the sea-blue histiocyte' in its distribution, ultrastructure and its association with splenic atrophy rather than splenomegaly.