[Lipid peroxidation intensity in the liver in protein-energy deficiency]

A fall in the glutathione peroxidase, glutathione reductase activity and selenium concentration was recorded in the liver of rats given diets poor in protein. The hepatic antioxidizing activity was lowered, lipid peroxidation (LPO) was intensified which was expressed in the growth of the amount of conjugated dienes, diene ketones and malonic dialdehydes. Diets poor in protein supplemented with sodium selenite and alpha-tocopherol acetate induced a significant increase in the selenium concentration and intensified the hepatic glutathione peroxidase and glutathione reductase activity. The rise in the oxide reductase activity was attended by a decreased rate of accumulation of LPO products, their amount being significantly lower as compared to that in the animals who were not given antioxidants.