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The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

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Published on: October 21, 2017

Choline: The Underconsumed and Underappreciated Essential Nutrient.

Taylor C Wallace^{1,2,3,4,5,6,7}, Jan Krzysztof Blusztajn^{1,2,3,4,5,6,7}, Marie A Caudill^{1,2,3,4,5,6,7}

¹is the principal and CEO at the Think Healthy Group, Inc, and is a adjunct professor in the Department of Nutrition and Food Studies at George Mason University.

Nutrition Today

|March 12, 2019

Summary

This summary is machine-generated.

Choline is an essential nutrient crucial for preventing liver damage and supporting neurodevelopment. Most Americans, including pregnant women, do not consume enough choline, increasing deficiency risks, especially for vegetarians and vegans.

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Hydroponics: A Versatile System to Study Nutrient Allocation and Plant Responses to Nutrient Availability and Exposure to Toxic Elements

Published on: July 13, 2016

Area of Science:

Nutritional Science
Biochemistry
Public Health

Background:

Choline is an essential nutrient with vital structural, metabolic, and regulatory functions.
Endogenous choline production is insufficient, necessitating exogenous intake to prevent deficiency.
The current Adequate Intake (AI) for choline was established without comprehensive population intake data.

Purpose of the Study:

To review the scientific literature and summit discussions on choline's role in human health.
To highlight the prevalence of inadequate choline intake across various population groups.
To emphasize choline's importance in pregnancy, lactation, and neurocognitive development.

Main Methods:

Narrative review of peer-reviewed literature.
Inclusion of discussions from the 2018 Choline Science Summit.
Analysis of existing data on choline intake and requirements.

Main Results:

Approximately 90% of Americans have choline intake below the AI.
Dietary patterns recommended by the 2015-2020 Dietary Guidelines for Americans are insufficient to meet choline AI.
Genetic variations can increase susceptibility to choline deficiency-related organ dysfunction.

Conclusions:

Maternal choline intake during pregnancy and lactation has lasting neurocognitive benefits for offspring.
Vegetarians and vegans are at higher risk of choline inadequacy due to its primary sources in animal-derived foods.
Improved communication regarding choline's role, especially in neurodevelopment, is critical for public health guidelines.