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Published on: December 1, 2016
Present and Future Prospect of Small Molecule & Related Targeted Therapy Against Human Cancer
Akshat Pathak1, Sanskriti Tanwar2, Vivek Kumar2
1Department of Computer Science and Engineering IMS Engineering College, Ghaziabad, Uttar Pradesh, India.
Abstract:
Cancer is uncontrolled cell growth guided by deregulation of cell growth network. Subsequently, alteration in genes occurs which influences expression (down-regulation of tumor suppressor genes and/or up-regulation of proto-oncogene) of these prominent cell growth proteins. Protein targeting has emerged as a hope against cancer. These therapies work by inhibiting or up regulating the target proteins through agents specific for treatment of deregulated proteins. Targeted cancer therapies are more favorable for cancers like lung, colorectal, breast, lymphoma and leukemia as they focus on particular molecular changes unique to a specific cancer. As researchers scrutinize and comprehend the cell changes that initiate cancer, they are better able to design promising therapies targeting these changes or nullify their effect. In present study we have assessed prospects of significant proteins which are known to be targeted by number of small molecules and related drugs for effective treatment of various forms of cancer. Moreover, we also addressed the efficacies of these drugs toward the cancer treatment and future challenges in their development as this information is lacking in previously published work.
Insights
Targeted cancer therapies offer new hope by focusing on specific protein alterations. This study assesses promising protein targets and small molecule drugs for effective cancer treatment and development.
Area of Science:
- Oncology
- Molecular Biology
- Drug Discovery
Background:
- Cancer arises from uncontrolled cell growth due to deregulation of cell growth networks.
- Gene alterations lead to changes in tumor suppressor genes and proto-oncogenes, affecting cell growth proteins.
- Targeted protein therapies offer a promising approach to cancer treatment.
Purpose of the Study:
- To assess the prospects of significant protein targets for small molecule drug development in cancer therapy.
- To evaluate the efficacy of existing drugs targeting these proteins.
- To address future challenges in the development of targeted cancer therapies.
Main Methods:
- Literature review and analysis of significant protein targets in cancer.
- Assessment of small molecules and drugs targeting these proteins.
- Evaluation of drug efficacy and identification of developmental challenges.
Main Results:
- Identified key proteins amenable to targeted therapy across various cancers.
- Summarized the efficacy of small molecule drugs against these protein targets.
- Highlighted current limitations and future directions for targeted cancer drug development.
Conclusions:
- Targeted protein therapies are effective for specific cancers like lung, colorectal, breast, lymphoma, and leukemia.
- Further research into novel protein targets and drug development is crucial for advancing cancer treatment.
- Addressing challenges in drug development will enhance the clinical application of targeted therapies.
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