Related Experiment Video
Updated: Jan 28, 2026
16:30
BioMEMS and Cellular Biology: Perspectives and Applications
Published on: October 1, 2007
10.2K
Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective.
Anja Ten Brinke1,2, Marc Martinez-Llordella3, Nathalie Cools4
1Department of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
Frontiers in Immunology
|March 12, 2019
Summary
Cellular therapies using tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) show promise for preventing transplant rejection and treating autoimmune diseases. Future research should focus on immunomonitoring to advance these clinical applications.
Area of Science:
- Immunology
- Cellular Therapy
- Transplantation Medicine
Background:
- Clinical applications of cellular therapies are expanding.
- Tolerance-inducing cells like tolAPC and Treg are key to these therapies.
- These therapies target transplant rejection and autoimmune diseases.
Purpose of the Study:
- Summarize current clinical perspectives of tolAPC and Treg.
- Address future directions in cellular therapy research.
- Highlight the importance of immunomonitoring in clinical studies.
Main Methods:
- Review of current clinical studies on tolAPC and Treg.
- Perspective on future research and clinical translation.
- Emphasis on immunomonitoring strategies.
Main Results:
- Clinical studies involving tolAPC and Treg have increased.
- These therapies offer potential for transplant and autoimmune disease treatment.
- Immunomonitoring is crucial for progress.
Conclusions:
- Tolerogenic antigen-presenting cells and regulatory T cells represent a promising frontier in cellular therapy.
- Further research and robust immunomonitoring are essential for successful clinical translation.
- Advancements in this field could significantly impact transplant and autoimmune disease management.
Related Concept Videos
01:27Psychodynamic Perspectives on Personality
1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
Psychodynamic theorists argue that unconscious...
1.6K
01:19The Behavioral Perspective on Personality
811
Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
811
01:23Criticisms of the Evolutionary Perspective
361
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
Evolutionary psychology provides one explanation for these findings, suggesting...
361
01:30Social Cognitive Perspective on Personality
1.0K
Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
01:14Changes in Skin Color: Clinical Perspectives
3.5K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.5K
00:59Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K