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Structural Basis for S100B Interaction with its Target Proteins.

K D Prez1, L Fan1

  • 1Department of Biochemistry, University of California Riverside, 900 University Ave, Riverside, California, USA.

Journal of Molecular and Genetic Medicine : an International Journal of Biomedical Research
|March 12, 2019
PubMed
Summary
This summary is machine-generated.

The S100B protein, a signaling molecule implicated in neurological diseases and cancer, binds to various partners. Combining sequence and structural analysis can uncover novel S100B interactions.

Keywords:
CancersDNA repairNeurological diseasesS100B-binding partnersTranscription factor TFIIHXPB helicasep53 Tumor suppressor

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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • S100B is a signaling protein involved in cellular processes.
  • Abnormal S100B levels are linked to neurological diseases and cancers.
  • S100B binds effector proteins in a calcium-dependent manner.

Purpose of the Study:

  • To validate the use of consensus sequence for identifying S100B target proteins.
  • To explore novel S100B-binding partners using combined sequence and structural analysis.
  • To highlight the potential of S100B in understanding human health and disease.

Main Methods:

  • Identified known S100B interacting proteins (e.g., CapZ, PKC, Hdm2/4, RAGE, p53).
  • Analyzed common binding surfaces and specific contacts on S100B.
  • Proposed integrating sequence homology and structural analysis for novel target discovery.

Main Results:

  • Established that S100B protein partners interact with a common surface area.
  • Demonstrated that specific contacts differentiate S100B target proteins.
  • Highlighted the XPB subunit of TFIIH as an example of a novel S100B partner identified through this approach.

Conclusions:

  • The combined approach of sequence homology and structural analysis is effective for identifying new S100B-binding partners.
  • S100B is implicated in diverse biological pathways, including transcription and DNA repair via proteins like XPB.
  • Further S100B research holds significant implications for human health and medicine.