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Updated: Jan 28, 2026
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Spin Saturation Transfer Difference NMR SSTD NMR: A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes
Published on: November 12, 2016
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Responsive paramagnetic chemical exchange saturation transfer MRI contrast agents.
1Department of Biomedical Engineering, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA and Department of Chemistry & Biochemistry, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Imaging in Medicine
|March 12, 2019
Summary
Proton exchange relaxation-enhanced T1 (PARACEST) agents offer molecular insights for predicting and assessing treatment effectiveness. This technology aids in delivering personalized medicine by enabling earlier therapeutic evaluations.
Area of Science:
- Biomedical Imaging
- Molecular Imaging
- Contrast Agents
Background:
- Proton exchange relaxation-enhanced T1 (PARACEST) agents provide molecular-level information.
- Current methods for assessing therapeutic effects can be time-consuming and lack early predictive power.
Purpose of the Study:
- To explore the potential of PARACEST agents in predicting and assessing therapeutic effects.
- To highlight the contribution of PARACEST agents to personalized medicine.
Main Methods:
- Utilizing PARACEST agents to acquire molecular-level data.
- Analyzing the data to correlate with therapeutic outcomes.
Main Results:
- PARACEST agents demonstrate the capability to provide crucial molecular insights.
- These insights hold significant potential for predicting treatment efficacy prior to therapy initiation.
Conclusions:
- PARACEST agents can facilitate earlier and more accurate assessments of therapeutic effects.
- The application of PARACEST agents supports the advancement of personalized medicine in clinical settings.
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