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Contribution of the BioFire® FilmArray® Meningitis/Encephalitis Panel: Assessing Antimicrobial Duration and Length of

Kyle Dack1, Stephanie Pankow2, Elizabeth Ablah1

  • 1University of Kansas School of Medicine-Wichita, Department of Preventive Medicine and Public Health, Wichita, KS.

Kansas Journal of Medicine
|March 12, 2019
PubMed
Abstract

Insights

The BioFire FilmArray Meningitis/Encephalitis Panel did not significantly decrease hospital length of stay or antimicrobial duration for meningitis patients. Traditional methods and the panel showed similar outcomes in this study.

Area of Science:

  • Clinical microbiology
  • Infectious disease diagnostics

Background:

  • Traditional meningitis diagnosis relies on CSF culture and Gram stain.
  • The BioFire FilmArray Meningitis/Encephalitis (ME) Panel offers a faster diagnostic approach.
  • Evaluating the clinical impact of the BioFire ME Panel is crucial for optimizing patient care.

Purpose of the Study:

  • To determine if the BioFire ME Panel reduces length of hospital stay for meningitis/encephalitis patients.
  • To assess if the BioFire ME Panel decreases antimicrobial treatment duration.
  • To compare diagnostic outcomes between traditional methods and the BioFire ME Panel.

Main Methods:

  • A historical-control study comparing patients before and after BioFire ME Panel implementation.
  • Chart review of patients with CSF pleocytosis.
  • Analysis of length of stay, antimicrobial duration, and diagnostic panel results.

Main Results:

  • No significant difference in average length of stay (approx. 4 days) between cohorts.
  • No significant difference in average antimicrobial duration (approx. 3 days) between cohorts.
  • The BioFire ME Panel identified positive bacterial/viral results in 42.6% of cases, with 77.8% of negative results still receiving antimicrobials.

Conclusions:

  • The BioFire ME Panel did not demonstrate a significant impact on reducing length of stay or antimicrobial duration.
  • Clinical outcomes for meningitis/encephalitis diagnosis remained similar with traditional methods versus the BioFire ME Panel.
  • Further research may be needed to fully elucidate the clinical utility of rapid diagnostic panels in meningitis management.
Keywords:
anti-infective agentsencephalitislength of staymeningitis

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