Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

9.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
9.1K
Hematopoiesis01:21

Hematopoiesis

8.9K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.9K
Aging01:26

Aging

667
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
667
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

16.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
16.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.5K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world, multi-omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS).

HemaSphere·2026
Same author

Genomic and transcriptomic differences between neuroendocrine neoplasms and carcinomas with human papillomavirus (HPV).

Infectious agents and cancer·2026
Same author

HSR26-247: Real-World Quality of Life in Patients Treated With Cemiplimab for Advanced Cutaneous Squamous Cell Carcinoma: Results of CemiplimAb Survivorship Epidemiology (CASE) Study.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

HSR26-247: Real-World Quality of Life in Patients Treated With Cemiplimab for Advanced Cutaneous Squamous Cell Carcinoma: Results of CemiplimAb Survivorship Epidemiology (CASE) Study.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Clinical, Genetic, and Pathologic Variability in Myelodysplastic Syndromes and Precursor Conditions Across Race, Ethnicity, and Sex.

American journal of hematology·2026
Same author

Molecular-Based Ecosystem to Improve Personalized Medicine in Chronic Myelomonocytic Leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same journal

The technical and ethical framework of fetal therapy: past and current advances.

Current stem cell reports·2025
Same journal

RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation.

Current stem cell reports·2025
Same journal

Transcription factors and splice factors - interconnected regulators of stem cell differentiation.

Current stem cell reports·2024
Same journal

Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It.

Current stem cell reports·2023
Same journal

Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling.

Current stem cell reports·2023
Same journal

Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility.

Current stem cell reports·2023
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.1K

Clonal Hematopoiesis in Aging.

Soo J Park1, Rafael Bejar1

  • 1Moores Cancer Center, University of California, San Diego, La Jolla, CA.

Current Stem Cell Reports
|March 12, 2019
PubMed
Summary
This summary is machine-generated.

Clonal hematopoiesis of indeterminate potential (CHIP) is a common aging-associated condition. CHIP reflects the interplay of stem cell aging and external factors, with variable clinical significance.

Keywords:
AgingCHIPClonal evolutionClonal hematopoiesisClonal selectionSomatic mutations

More Related Videos

Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized Tissues
07:41

Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized Tissues

Published on: October 23, 2019

15.6K
In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

13.6K

Related Experiment Videos

Last Updated: Jan 28, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.1K
Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized Tissues
07:41

Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized Tissues

Published on: October 23, 2019

15.6K
In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

13.6K

Area of Science:

  • Hematology
  • Genetics
  • Aging Research

Background:

  • Clonal hematopoiesis of indeterminate potential (CHIP) involves somatic mutations in aging hematopoietic stem cells (HSCs).
  • CHIP is increasingly recognized as a common, age-related phenomenon.

Purpose of the Study:

  • To review current understanding of mechanisms driving clonal hematopoiesis with aging.
  • To explore the clinical implications, both malignant and non-malignant, of CHIP.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on mechanisms influencing clonal development and clinical consequences.

Main Results:

  • Hematopoietic system aging promotes clonal dominance through phenotypic changes.
  • Cell-extrinsic factors exert selective pressures influencing clonal architecture.
  • Small clones with driver mutations are common in aging and often benign, potentially compensating for reduced HSC capacity.

Conclusions:

  • CHIP signifies biological interplay between HSC aging and cell-extrinsic factors.
  • The clinical significance of CHIP is context-dependent and highly variable.
  • Further research is needed to clarify causal relationships and confounding factors for CHIP's role in aging and clinical outcomes.