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Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

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Phantom Validation of DCE-MRI Magnitude and Phase-Based Vascular Input Function Measurements.

Warren Foltz^1,2, Brandon Driscoll¹, Sangjune Laurence Lee²

¹Department of Medical Physics, Princess Margaret Cancer Center and University Health Network, Toronto, ON, Canada.

Tomography (Ann Arbor, Mich.)

|March 12, 2019

Summary

This summary is machine-generated.

Arterial input function (AIF) measurements using MRI phase signals (AIF_PHA) were found to be more accurate and robust than those using MRI magnitude signals (AIF_MAGN) when compared to CT (AIF_CT). AIF_PHA demonstrated superior performance across various conditions.

Keywords:

MRI phase arterial input function (AIF)dynamic contrast-enhanced MRI (DCE-MRI)permeability phantom quantification

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Area of Science:

Medical Imaging
Biophysics
Radiology

Background:

Accurate patient-specific arterial input functions (AIF) are crucial for model-based analysis of vascular permeability.
Magnetic resonance imaging (MRI) offers potential for AIF measurement, but its accuracy is affected by various factors.

Purpose of the Study:

To investigate factors influencing AIF measurements from MRI magnitude (AIF_MAGN) and phase (AIF_PHA) signals.
To compare MRI-derived AIFs against computed tomography (CT) AIFs (AIF_CT) under controlled conditions.

Main Methods:

A multimodality flow phantom was used with varying flip angles, flow rates, and contrast agent concentrations.
MRI 3D-FLASH signals and variable flip angle T1 profiles were measured to assess in-flow and radiofrequency biases.
Gd-DTPA concentrations derived from MRI magnitude and phase signals were compared to AIF_CT using Pearson correlation.

Main Results:

AIF_MAGN was sensitive to imaging orientation, spatial location, flip angle, and flow rate, significantly underestimating AIF_CT peak concentrations.
Converting AIF_MAGN to Gd-DTPA concentration using orientation- and flow-matched T1 improved accuracy but remained variable above 2.5 mM.
AIF_PHA performed equivalently to AIF_CT within 1 mM across all tested conditions, demonstrating superior robustness.

Conclusions:

MRI phase-derived arterial input functions (AIF_PHA) provide a more robust and accurate measurement compared to magnitude-derived AIFs (AIF_MAGN).
AIF_PHA demonstrates reliable performance equivalent to AIF_CT across a wide range of physiological conditions.
AIF_PHA shows significant promise for accurate patient-specific AIF quantification in clinical settings.