Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.3K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

864
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
864
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

621
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
621
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
Genetics of Speciation02:16

Genetics of Speciation

21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a Therapeutic Drug Monitoring Strategy for Adalimumab in Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study.

Clinical and translational science·2026
Same author

The Evolving Microbial Paradigm in Acne.

Biomolecules·2026
Same author

Aspartyl protease MfSAP2 is a key virulence factor in mycelial form of skin fungi Malassezia furfur.

The Biochemical journal·2025
Same author

Ruxolitinib Alleviates Inflammation and Fortifies Skin Barrier Function Through Dampening IL-13.

Experimental dermatology·2025
Same author

Mendelian randomization identifies OX40 as a potential mediator of the effects of cigarette smoking on palmoplantar pustulosis.

The British journal of dermatology·2025
Same author

Efficacy and Safety of Apremilast Over 52 Weeks in Patients with Plaque Psoriasis in High-Impact Areas and Impaired Quality of Life.

Dermatology and therapy·2025
Same journal

Durability of Response to Icotrokinra in Adults With Moderate-to-Severe Plaque Psoriasis: One-Year Results From the Phase 3, Placebo- and Active Comparator-Controlled ICONIC-ADVANCE 1 & ICONIC-ADVANCE 2 Trials.

The British journal of dermatology·2026
Same journal

Clinicopathological features of lymphocytic thrombophilic arteritis and the relationship with livedoid vasculopathy - a case series of 36 patients.

The British journal of dermatology·2026
Same journal

Improving Prognostication for Cutaneous Squamous Cell Carcinoma.

The British journal of dermatology·2026
Same journal

Recurrent and novel GLTP variants in five patients with nonsyndromic epidermal differentiation disorder: phenotypic and genotypic expansion.

The British journal of dermatology·2026
Same journal

Sustained efficacy of dupilumab in pediatric patients with moderate-to-severe atopic dermatitis over 1 year.

The British journal of dermatology·2026
Same journal

EPHX3-nEDD: from molecular diagnosis to epidermal lipid biology.

The British journal of dermatology·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
03:10

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

3.6K

What does acne genetics teach us about disease pathogenesis?

J E A Common1, J N Barker2, M A M van Steensel1,3

  • 1Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.

The British Journal of Dermatology
|March 12, 2019
PubMed
Summary
This summary is machine-generated.

Genetic studies are uncovering the basis of acne vulgaris, a common inflammatory skin condition. Research into rare disorders is revealing key mechanisms for pilosebaceous biology, aiding understanding of acne pathogenesis.

More Related Videos

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
06:56

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

11.1K
Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

13.9K

Related Experiment Videos

Last Updated: Jan 28, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
03:10

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

3.6K
Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
06:56

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

11.1K
Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

13.9K

Area of Science:

  • Dermatology
  • Genetics
  • Molecular Biology

Background:

  • Acne vulgaris is a common inflammatory skin condition with a complex genetic basis.
  • Familial aggregation suggests a significant hereditary component, yet specific genetic associations were historically elusive.
  • Understanding the genetic underpinnings of acne vulgaris is crucial for developing effective treatments.

Purpose of the Study:

  • To review recent advancements in understanding the genetic basis of acne vulgaris.
  • To highlight the role of high-resolution genotyping and studies of rare disorders in acne research.
  • To identify future research directions for mechanistic investigations and therapeutic target discovery.

Main Methods:

  • Large-scale genetic association studies utilizing high-resolution genotyping arrays.
  • Family-based and cross-sectional study designs.
  • Investigation of rare genetic disorders presenting with acne or acne-like lesions.

Main Results:

  • Genetic loci and candidate genes associated with acne vulgaris have been identified through large-scale studies.
  • Studies of rare disorders have illuminated critical biological pathways and mechanisms in pilosebaceous biology relevant to acne.
  • While genetic associations are emerging, the functional consequences of identified variants remain largely unelucidated.

Conclusions:

  • Further in-depth mechanistic studies are required to pinpoint key molecular players in acne pathogenesis.
  • Dissecting candidate molecular pathways offers potential for identifying novel druggable targets for acne vulgaris treatment.
  • Integrating findings from genetic association studies and rare disorder research will advance our understanding and treatment of acne.