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Updated: Jan 28, 2026
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Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
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GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure
Tatsuo Itakura1, Andrew Webster1, Shravan K Chintala1
11 USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
Summary
GPR158, a G-protein-coupled receptor, regulates intraocular pressure and stress hormone response in the visual system. Its absence negates epinephrine's pressure-lowering effect, suggesting it as a potential drug target for ocular hypertension.
Area of Science:
- Neuroscience
- Ophthalmology
- Molecular Biology
Background:
- GPR158 is a newly identified G-protein-coupled receptor implicated in biological stress responses.
- Previous studies linked GPR158 to ocular hypertension induced by glucocorticoids.
Purpose of the Study:
- To investigate the function of GPR158 within the visual system.
- To explore its role in regulating intraocular pressure and cellular stress.
Main Methods:
- Gene expression and protein immunolocalization in mouse and human brain and eye tissues.
- Analysis of GPR158 function in GPR158 knockout mice and human trabecular meshwork cells.
- Gene overexpression studies in cell cultures to assess cAMP production and cell survival.
Main Results:
- GPR158 is highly expressed in the visual cortex, retina (photoreceptors, ganglion cells), and trabecular meshwork.
- GPR158 deficiency offered transient protection against age-related intraocular pressure increase but negated epinephrine's pressure-lowering effect.
- Overexpression enhanced cAMP production and improved cell survival under oxidative stress, involving the TP53 pathway.
Conclusions:
- GPR158 acts as a homeostatic regulator of intraocular pressure.
- GPR158 is a potential pharmacological target for managing ocular hypertension and glaucoma.
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